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i dont know about on the 6 cylinder, but i ran it directly through my vacuum line on my brake booster. while the engine was warm and running. i wouldn't recommend putting it through the engine oil, as i have seen some bad stuff happen when loosening up sludge. you can put it in the gasoline to clean your fuel injectors/remove moisture from system. at the same time they say it lubes the upper part of the cylinder such as valves. i ran it through the vacuum line to clean out the carbon in my engine. it seemed to help a lot. i had better throttle response and better gas mileage. the acceleration was much smoother and the truck just seemed to run better overall.

just follow the instructions on the back of the can.
 
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