In general, the slower you drive in top gear, the better your mileage will be. I use 5th gear as often as I can. Many of the roads around here have a speed limit of 45 mph, and at that speed in 5th, my engine speed is around 2000-2200 rpm...pretty good for gas mileage. If I get out on the Interstate, and drive 70 mph, the engine speed is up around 3000 rpm...not as good for gas mileage, but I have no choice, as there's no 6th gear.
To get the best mileage, drive in the highest gear you can reasonably drive in. Nissan actually recommends (this is for '95 models) the following speeds as shift points:
1-2: 15 mph
2-3: 25 mph
3-4: 40 mph
4-5: 45 mph
That shift schedule produces an upshift when the engine is in the 3000-3500 rpm range. I usually shift a little sooner, when I can. I'm usually in the next higher gear somewhere between 2500 and 3000 rpm on the tach. This is all everyday driving, mind you. Out on the Interstate, I'll be in 4th gear sometimes to pull some of the hills, and that's a sustained engine speed of 3500-4000 rpm sometimes -- pretty poor for mileage. But sometimes you gotta do what you gotta do.
