I'm not quite sure on what an 'interference' engine is, exactly. Someone else on this forum oughta know.
EDIT: Oh, do you mean if the valves can be struck by the pistons? If the timing is off, I suppose so. The pistons in the truck are flathead, but I'm not sure how much room the chamber provides at top-dead center. It could be a possibility.
If you're replacing the cam, make sure it's perfect.
